how to get trodusquemine

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We May Have Just Developed A Drug That Can 'Melt' Heart-Clogging Body Fat Away!Health news Diabetes Medicines could also help treat heart disease Researchers say that drug throdusquemine has the potential to reduce blood fat and may reverse atherosclerosis. Can an experimental diabetes medicine change how we treat heart disease? In a new study, researchers took advantage of the ability of drug trodusquemine to "reduce" blood fat in preclinical trials involving mice. The , performed at the University of Aberdeen in Scotland, is the first of its kind to demonstrate the ability to reverse the medication, in some cases with as little as a dose. "We could prove that the use of drugs chronically, once a week for five weeks or once towards the end of the study, both resulted in a significantly lower atherosclerotic plaque area. He also lowered the serum lipids (triglycerides and cholesterol), told Healthline Mirela Delibegovic, author of studies and professor in diabetic medicine at the University of Aberdeen. The mice in the study were treated with saline (for the control group), a single dose of trodusquemine or several doses. For mice that received single or multiple doses, there was a decrease in the formation of a measured plate while the control group remained unchanged. The study in Aberdeen is exciting because, in , "[The drug] seemed to completely reverse the effects of atherosclerosis." Cardiac disease is the main cause of death for men and women in the United States, according to . It is estimated that 6100,000 people die a year for heart disease in the United States, which represents approximately 25% of all deaths a year. In addition, more than 700,000 Americans will have a heart attack every year. Atherosclerosis, the narrowing of the arteries caused by a fat plaque buildup, is a major cause of heart attack and stroke. While the condition is present in all people to a certain extent, it gets worse as it ages. It can be affected by many lifestyle factors, such as diet, activity level and smoking. Atherosclerosis slows blood flow to and from the heart, leading to coronary heart disease, angina and other more severe health complications. Occlusion, blocking a blood vessel, may result in serious and sometimes fatal heart incidents. The plaque can also be removed from the blood vessel leading to a blood clot (thrombosis). Trodusquemine works by inhibiting PTP1B, an enzyme in the body that has a role in the regulation of insulin. Researchers have that the medication is effective in correcting insulin resistance induced by obesity, suppressing appetite and . It can also help in treating diabetes, making the drug's potential even more intriguing. "Cardiovascular disease is the most common cause of mortality in diabetic patients, due to accelerated atherosclerosis. Thus, drugs that could improve both the diabetic state and decrease atherosclerotic progression can have the promise of future therapies," said Delibegovic. There is also a strong connection between diabetes, heart disease and atherosclerosis. Being able to treat obesity, diabetes and atherosclerosis with a medicine would be innovative. Atherosclerosis is considered a low-level chronic inflammatory disease, which is accelerated by diabetes. Previous studies showed that diabetes worsened atherosclerosis. In identified the biological mechanisms for why this occurred. "We have known for several years that PTP1B protein inhibition should result in positive results in insulin sensitivity throughout the body. We have now added to the evidence that it is also positive in the development of atherosclerosis," Delibegovic said. At this time, trodusquemine is in early clinical trials for breast cancer and breast cancer. More studies will be required to test whether the drug's ability to reverse atherosclerosis is possible in humans. Delibegovic and his colleagues hope to continue their research on drugs. He says that they are currently requesting funding to conduct human trials. "We plan to continue our research moving towards the human environment now that we have positive preclinical data," Delibegovic said. Read this now.

This site is optimized for modern browsers. For the best experience, use Google Chrome, Mozilla Firefox, or Microsoft Edge. New heart disease medicine that will be made available through an innovative clinical trial During the next decade, up to 30,000 lives could be saved thanks to a proposal of government collaboration with the pharmaceutical company Novartis to face heart disease, a leading cause of death in the UK. The drug still pending approval will include, a cholesterol reduction treatment, will be studied in patients in the UK as part of a large-scale NHS clinical trial that is expected to begin at the end of this year. In addition, at a global level, the drug is expected to be available through a population-level agreement, pioneering a game-changing approach to reducing the risk of heart disease. The trial will be delivered by the NIHR Clinical Research Network (CRN), who, in collaboration with NHS England, Oxford University and Novartis, will pilot an innovative approach to identify, recruit and follow a group of large-scale patients. Patients who meet the necessary conditions will be identified through the NHS digital screening patient records at the national level and will be contacted to attend a screening visit at one of the 40 test centers. These centers will be in community settings to reach the people where they live. The first results of clinical trials suggest that if 300,000 patients are included annually, it could help prevent 55,000 heart attacks and strokes, and it has the potential to save 30,000 lives in the next 10 years. Heart disease is the largest killer in the world and the second largest cause of death in the United Kingdom, with more than three million people suffering from atherosclerotic cardiovascular disease and two and a half million who currently depend on statins to lower their cholesterol. Recent tests have shown inclisiran can reduce bad cholesterol in just two weeks. Matt Cooper, CRN Business Development and Marketing Director, said: "This innovative collaboration between NIHR, the life sciences industry and NHS means improving the UK's position as a global leader in the development of revolutionary drugs, with the potential to deal with the conditions that affect a large number of people." The NIHR Clinical Research Network offers a globally unique support package that allows the life science industry to offer high-quality clinical research studies to a large number of people within the UK health service." Health Secretary Matt Hancock said: "As a Health Secretary, I am determined to find ways to save as many lives as possible, and make my best effort to stop the terrible conditions like heart disease from taking people from your family and friends too soon. "This partnership is a fantastic news and it's a big step forward in helping to achieve this. This collaboration has the potential to save 30,000 lives in the next ten years and is proof that the United Kingdom remains the world's leading destination for revolutionary medical care. Notes to the blog EditorTop storiesNIHR

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